2019

Picardo MCD, Sugimura YK, Dorst KE, Kallurkar PS, Akins VT, Ma X, Teruyama R, Guinamard R, Kam K, Saha MS, Del Negro CA (2019). Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm. PLoS Biology, 17(2): e2006094. PMID: 30789900.

Kallurkar PS, Grover C, Picardo MCD, Del Negro CA (2019). Evaluating the burstlet theory of inspiratory rhythm and pattern generation. eNeuro, in press (accepted Dec. 17, 2019). PMID: 00000000.

2018

Del Negro CA, Funk GD, and Feldman JL (2018). Breathing matters. Nat Rev Neurosci 19(6): 351-367 PMID: 29740175.

Vann NC, Pham FD, Dorst KE, and Del Negro CA (2018). Dbx1 pre-Bötzinger complex interneurons comprise the core inspiratory oscillator for breathing in unanesthetized adult mice. eNeuro 5(3) 10.1523/ENEURO.0130-18.2018. PMID: 29845107.

Phillips WC, Del Negro CA, and Rekling JC (2018). Dendritic A-current in rhythmically active preBötzinger complex neurons in organotypic cultures from newborn mice. J Neurosci, 38(12): 3039-3049. PMID: 29459371.

2017

Hayes, JA§, Kottick A§, Picardo MCD§, Halleran AD, Smith RD, Smith GD, Saha MS*, and Del Negro CA* (2017). Transcriptome of neonatal preBötzinger complex neurones in Dbx1 reporter mice. Sci Rep, 7(1): 8669 doi: 10.1038/s41598-017-09418-4. PMID: 28819234.

§ indicates co-first authors

* indicates co-last authors

Akins VT, Weragalaarachchi K, Picardo MCD, Revill AK, and Del Negro CA (2017). Morphology of Dbx1 respiratory neurons in the preBötzinger complex and reticular formation of neonatal mice. Sci Data, 4:170097 doi: 10.1038/sdata.2017.97 PMID: 28763053

Kottick A, Martin CA, and Del Negro CA (2017). Fate mapping neurons and glia derived from Dbx1-expressing progenitors in mouse preBötzinger complex. Physiol Rep, 5(11), e13300. PMID: 28611151.

2016

Vann NC, Pham FD, Hayes JA, Kottick A, and Del Negro, CA (2016). Transient suppression of Dbx1 preBötzinger interneurons disrupts breathing in adult mice. PLoS One, 11(9), e0162418. PMID: 27611210.

Song H, Hayes JA, Vann NC, Wang X, LaMar MD, and Del Negro, CA (2016). Functional interactions between mammalian respiratory rhythmogenic and premotor circuitry. J Neurosci, 36(27), 7223-33. PMID: 27383596

Phillips, WC, Herly, M, Del Negro, CA, and Rekling, JC (2016). Organotypic slice cultures containing the preBötzinger complex generate respiratory-like rhythms. J Neurophysiol, 115(2), 1063-70. PMID: 26655824.

2015

Revill, AL, Vann, NC, Akins, VT, Kottick, A, Gray, PA, Del Negro, CA*, and Funk, GD* (2015). Dbx1 precursor cells are a source of inspiratory XII premotoneurons. Elife, e12301. PMID: 26687006.

Kottick A & Del Negro CA (2015). Synaptic depression influences inspiratory-expiratory phase transition in Dbx1 interneurons of the preBötzinger Complex in neonatal mice. J Neurosci, 35(33), 11606-11. PMID: 26290237.

Song H, Hayes JA, Vann NC, LaMar D & Del Negro CA (2015). Mechanisms leading to rhythm cessation in the respiratory preBötzinger complex due to piecewise cumulative neuronal deletions. eNeuro, 2(4) DOI: 10.1523/ENEURO.0031-15.2015. PMID: 26465010.

2014

Wang X, Hayes JA, Revill AL, Song H, Kottick A, Vann NC, LaMar MD, Picardo MC, Akins VT, Funk GD & Del Negro CA (2014). Laser ablation of Dbx1 neurons in the pre-Bötzinger Complex stops inspiratory rhythm and impairs output in neonatal mice. Elife, e03427. PMID: 25027440

Ruangkittisakul A, Kottick A, Picardo MCD, Ballanyi K & Del Negro CA (2014). Identification of the pre-Bötzinger complex inspiratory center in calibrated “sandwich” slices from newborn mice with fluorescent Dbx1 interneurons. Physiol Rep 2, e12111. PMID: 25138790

Tupal S, Huang W-H, Picardo MC, Ling G-Y, Del Negro CA, Zoghbi HY & Gray PA (2014). Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice. Elife, e02265. PMID: 24842997

Guinamard R, Hof T & Del Negro CA (2014). The TRPM4 channel inhibitor 9-phenanthrol. Br J Pharmacol 171, 1600–1613. PMID: 24433510

Nordman JC, Phillips WS, Kodama N, Clark SG, Del Negro CA & Kabbani N (2014). Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth. J Neurochem 129, 649–662. PMID: 24350810

2013

Feldman JL, Del Negro CA & Gray PA (2013). Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol 75, 423–452.PMID: 23121137

Picardo MCD, Weragalaarachchi KTH, Akins VT & Del Negro CA (2013). Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Bötzinger complex of neonatal mice. J Physiol (Lond) 591, 2687–2703.PMID: 23459755

Wang X, Hayes JA, Picardo MCD & Del Negro CA (2013). Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue. J Physiol (Lond) 591, 2393–2401. PMID: 23440965

Guinamard R, Simard C & Del Negro C (2013). Flufenamic acid as an ion channel modulator. Pharmacol Ther 138, 272–284.PMID: 23356979

2012

Hayes JA, Wang X & Del Nergo CA (2012). Cumulative lesioning of respiratory interneurons disrupts and precludes motor rhythms in vitro. PMID: 22566628

2011

Del Negro CA, Hayes JA & Rekling JC (2011). Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons. J Neurosci 31, 1017–1022.PMID: 21248126

Del Negro CA (2011). Disparate purinergic modulation of respiration in rats and mice. J Physiol (Lond) 589, 4409–4410.PMID: 21921138

Dunmyre JR, Del Negro CA & Rubin JE (2011). Interactions of persistent sodium and calcium-activated nonspecific cationic currents yield dynamically distinct bursting regimes in a model of respiratory neurons. J Comput Neurosci 31, 305–328.PMID: 21234794

2010

Gray PA, Hayes JA, Ling GY, Llona I, Tupal S, Picardo MCD, Ross SE, Hirata T, Corbin JG, Eugenín J & Del Negro CA (2010). Developmental origin of preBötzinger complex respiratory neurons. J Neurosci 30, 14883–14895.PMID: 21048147

Krey RA, Goodreau AM, Arnold TB & Del Negro CA (2010). Outward Currents Contributing to Inspiratory Burst Termination in preBötzinger Complex Neurons of Neonatal Mice Studied in Vitro. Front Neural Circuits 4, 124.PMID: 21151816

Del Negro CA, Hayes JA, Pace RW, Brush BR, Teruyama R & Feldman JL (2010). Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals. Prog Brain Res 187, 111–136.PMID: 21111204

2009

Del Negro CA, Kam K, Hayes JA & Feldman JL (2009). Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiol (Lond) 587, 1217–1231.PMID: 19171658

Rubin JE, Hayes JA, Mendenhall JL & Del Negro CA (2009). Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. Proc Natl Acad Sci USA 106, 2939–2944.PMID: 19196976

2008

Hayes JA, Mendenhall JL, Brush BR & Del Negro CA (2008). 4-Aminopyridine-sensitive outward currents in preBötzinger complex neurons influence respiratory rhythm generation in neonatal mice. J Physiol (Lond) 586, 1921–1936.PMID: 18258659

Del Negro CA & Hayes JA (2008). A “group pacemaker” mechanism for respiratory rhythm generation. J Physiol (Lond) 586, 2245–2246.PMID: 18450782

Nesse WH, Negro CAD & Bressloff PC (2008). Oscillation regularity in noise-driven excitable systems with multi-time-scale adaptation. Phys Rev Lett 101, 088101.PMID: 18764664

Pace RW & Del Negro CA (2008). AMPA and metabotropic glutamate receptors cooperatively generate inspiratory-like depolarization in mouse respiratory neurons in vitro. Eur J Neurosci 28, 2434–2442.PMID: 19032588

2007

Crowder EA, Saha MS, Pace RW, Zhang H, Prestwich GD & Del Negro CA (2007). Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex. J Physiol (Lond) 582, 1047–1058.PMID: 17599963

Hayes JA & Del Negro CA (2007). Neurokinin receptor-expressing pre-botzinger complex neurons in neonatal mice studied in vitro. J Neurophysiol 97, 4215–4224.PMID: 17409172

Pace RW, Mackay DD, Feldman JL & Del Negro CA (2007a). Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation. J Physiol (Lond) 580, 485–496.PMID: 17272351

Pace RW, Mackay DD, Feldman JL & Del Negro CA (2007b). Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. J Physiol (Lond) 582, 113–125.PMID: 17446214

2006

Feldman JL & Del Negro CA (2006). Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci 7, 232–242. PMID: 16495944

2005

Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA & Feldman JL (2005). Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. J Neurosci 25, 446–453.PMID: 15647488

2004

Sekerli M, Del Negro CA, Lee RH & Butera RJ (2004). Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies. IEEE Trans Biomed Eng 51, 1665–1672.PMID: 15376515

2002

Del Negro CA, Koshiya N, Butera RJ Jr & Smith JC (2002a). Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro. J Neurophysiol 88, 2242–2250.PMID: 12424266

Del Negro CA, Morgado-Valle C & Feldman JL (2002b). Respiratory rhythm: an emergent network property? Neuron 34, 821–830.PMID: 12062027

Del Negro CA, Wilson CG, Butera RJ, Rigatto H & Smith JC (2002c). Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network. Biophys J 82, 206–214.PMID: 11751309

2001

Butera RJ, Wilson CG, Delnegro CA & Smith JC (2001). A methodology for achieving high-speed rates for artificial conductance injection in electrically excitable biological cells. IEEE Trans Biomed Eng 48, 1460–1470.DOI: 10.1109/10.966605

Del Negro CA, Johnson SM, Butera RJ & Smith JC (2001). Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions. J Neurophysiol 86, 59–74.PMID: 11431488

2000

Butera Jr. RJ, Johnson SM, DelNegro CA, Rinzel J & Smith JC (2000). Dynamics of excitatory networks of bursting pacemaking neurons: Modeling and experimental studies of the respiratory central pattern generator. Neurocomputing 32–33, 323–330.

Smith JC, Butera RJ, Koshiya N, Del Negro C, Wilson CG & Johnson SM (2000). Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Respir Physiol 122, 131–147.PMID: 10967340

1999

Del Negro CA, Hsiao CF & Chandler SH (1999). Outward currents influencing bursting dynamics in guinea pig trigeminal motoneurons. J Neurophysiol 81, 1478–1485.PMID: 10200184

1998

Hsiao CF, Del Negro CA, Trueblood PR & Chandler SH (1998). Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. J Neurophysiol 79, 2847–2856.PMID: 9636091

Del Negro CA & Chandler SH (1998). Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors. J Neurosci 18, 9216–9226.PMID: 9801361

Del Negro CA, Hsiao CF, Chandler SH & Garfinkel A (1998). Evidence for a novel bursting mechanism in rodent trigeminal neurons. Biophys J 75, 174–182.PMID: 9649377

1998

Del Negro CA & Chandler SH (1997). Physiological and theoretical analysis of K+ currents controlling discharge in neonatal rat mesencephalic trigeminal neurons. J Neurophysiol 77, 537–553.PMID: 9065827