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Welcome to the Poutsma Group J. C. Poutsma Garrett-Robb-Guy Professor of Chemistry Garrett-Robb-Guy Chair 2017-2022 English-Stonehouse Faculty Fellow 2013-2015 2011 Plumeri Award for Faculty Excellence 2008 Professeur Invitee, Universite Pierre et Marie Curie B.S., Furman University
1991 (757)-221-2548; e-mail: jcpout@wm.edu |
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Courses Research Interests
Current Students
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Chem. 103 General Chemistry (Fall 2018) Chem. 302, Second Semester Physical Chemistry Chem. 303 Integrated physical/analytical lab I (Fall 2018) Chem. 304 Integrated physical/analytical lab II Chem. 309, Principles of Instrumental Analysis Chem. 404, Advanced Analytical Chemistry Chem. 408 Computational Methods in Chemistry Chem. 460 Mass
Spectrometry (Spring 2018) We use mass spectrometry and high-level theoretical calculations to study the intrinsic properties of gas-phase biomolecules. We are especially interested in the chemistry of so called “non-protein amino acids”, which are naturally-occurring compounds that are not coded by RNA. These species serve as model systems for us to understand the subtle interplay between structure and function in biological molecules. Current projects in the lab include: 1) Gas-phase thermochemistry of protein and non-protein amino acid using the extended kinetic method. 2) Peptide fragmentation mechanisms 3) Hydrogen-deuterium exchange of biomolecules 4) Infrared multiphoton dissociation spectroscopy 5) Studies of entropy effects in the kinetic method 6) Proteomics studies of bacteriophages and
mycobacteria We have a variety of
instrumentation in our lab, including:
Research Group (Poutsma's Army)
Former Students (Rogue's Gallery) Group Photos
National Science Foundation CSDM-B CHE-1800137 (2018-2021) National Institutes
of Health R15 (2015-2019)
William and Mary Students are Underlined 39 “Infrared
Multiple Photon Dissociation Spectroscopy of Cationized
Canavanine: Side-Chain Substitution Influences
Gas-Phase Zwitterion Formation.” Smith, Z. M.;
Steinmetz, V.; Martens, J.; Oomens, J.; Poutsma*, J. C. Int. J. Mass Spectrom., 2018, 429, 158. 38. “Metal Substitution and Solvomorphism in Alkylthiolate-Bridged Zn3 and HgZn2 Metal Clusters.” Hallinger, M. R.; Gerhard, A. C.; Ritz, M. D.; Sacks, J. S.; Poutsma, J. C.; Pike, R. D.; Wojtas, L.; Bebout*, D. C. ACS Omega 2017, 2, 6391. 37. “C–H…O Hydrogen Bonding in Pentamers of Isatin.” Silski, A. M.; Brown, R. D.; Petersen, J. P.; Coman, J. M.; Turner, D. A.; Smith, Z. M.; Corcelli, S. A.; Poutsma, J. C.; Kandel*, S. A. J. Phys. Chem. C. 2017, 121, 21520. 36. “Infrared Multiple-photon Dissociation Action Spectroscopy of the b2+ ion from PPG: Evidence of third residue affecting b2+ fragment structure.” Poutsma*, J.C.; Martens, J.; Oomens J.; Maitre, P.; Steinmetz, V.; Bernier, M.; Jia, M.; Wysocki*, V. H. J. Am. Soc. Mass Spectrom., 2017, 28, 1482-1488. 35. “Infrared Spectroscopic Confirmation of α-Lactone Formation in the Dissociation of a Gaseous Amino Acid”, Wenthold*, P. G.; Koirala,D.; Somogyi, A.; Poutsma, J. C. J. Phys. Org. Chem., 2017, 30, e3606. 34. “Investigation of Proton Affinities, Dimer Equilibria, and Gas Phase Vibrational Spectra of Protonated Nucleosides, Deoxynucleosides, and Their Analogues” Ung, H. U.; Arias, E.; Huynh, K. T.; Poutsma, J. C.; Oomens, J.; Berden, G.; Morton, T. H. Int. J. Mass Spectrom., 2015, 378, 294. 33. Gas-Phase Acid-Base Properties of 1-Aminocycloalkane-1-Carboxylic Acids from the Extended Kinetic Method.” Muetterties, C; Drissi Touzani, A.; Hardee, I.; Huynh, K. T.; and Poutsma, J. C. Int. J. Mass Spectrom., 2015, 378, 59. 32. “Investigations of the Mechanism of the "Proline Effect" in Mass Spectrometry Peptide Fragmentation Experiments: the “Pipecolic Acid Effect.” Raulfs, M. M.; Breci, L.; Bernier, M., Hamdy, O.; Janiga, A.;Wysocki., V.; Poutsma, J. C. J. Am. Soc. Mass Spectrom., 2014, 25, 1705. 31. “Gas-Phase
Acid-Base Properties of Homocysteine, Homoserine,
5-Mercaptonorvaline, and 5-Hydroxynorvaline from the Extended Kinetic
Method.” Muetterties, C.; Janiga, A.;
Huynh, K. T.; Pisano, M. G.;
Tripp, V. T.; Young, D. D.; and Poutsma, J. C. Int. J. Mass Spectrom., 2014, 369, 71. 30. “Macrocyclic (CdS)6 Bis-carbonato
Complex Self-Assembly” Lai, W.; Berry, S.; Tran, A.; Kaplin, W.; Hain, M.; Poutsma, J.;
Butcher, R.; Pike, R.; Bebout*, D. Inorg. Chem., 2013, 52, 2286. 29. “Gas-Phase Hydrogen Deuterium Exchange of Lysine Homologs” Arrington, J. V; Straus, R.; Reynolds, P. F.; Poutsma, J. L.; Marzluff, E. M.; Poutsma, J. C., Int. J. Mass Spectrom., 2012, 330-332, 200. 28. "Gas-Phase
Acidities of Lysine Homologues and Proline Analogs from the Extended Kinetic
Method" Webb, I.; Muetterties, C.; Platner, C. B.; Poutsma, J. C Int. J. Mass
Spectrom. 2012 316-318, 126. 27. “A
Synthetic Model of Hg(II) Sequestration” Viehweg,
J. A.; Stamps, S. M.; Dertinger, J. J.; Green, R.
L.; Harris, K. E.; Butcher, R. J.; Andriole, E. J.; Poutsma, J. C.; Berry, S. M.; Bebout*, D. C. J.
Chem. Soc. Dalton Trans 2010, 39, 3174. 26. “The Curtin-Hammett Principle in Mass
Spectrometry” Haupert, L.; Poutsma*, J. C.; Wenthold*, P. G. Acc. Chem. Res., 2009, 42, 1480. 25. “IRMPD Spectroscopy Shows That AGG
Forms an Oxazolone b2+ Ion” Yoon, S.H; Chamot-Rooke, J; Perkins, B. R.; Hilderbrand,
A.; Poutsma, J. C.; Wysocki*, V. H. J.
Am. Chem. Soc. 2008, 130, 17644. 24. “Gas Phase Acidities of the 20 Protein Amino Acids” Jones, C. M.; Bernier, M.; Colyer, K. E; Carson, E.; Metz, R. Pawlow, A; Webb, I. K.; Wischow, E. D.; Andriole, E. J.; Poutsma, J. C. Int. J. Mass Spectrom, 2007, 267, 54. 23. “Are Carboxyl Groups the Most Acidic
Sites in Amino Acids? Gas Phase
Acidity, H/D Exchange Experiments, and Computations on Cysteine and It’s Conjugate Base” Tian, Z.; Pawlow,
A.; Poutsma*, J. C.; Kass*, Steven R. J. Am. Chem. Soc. 2007,
129, 5403. 22. “Absolute Rate Coefficients and Branching Percentages for the reactions of POxCly– + N (4S3/2) and POxCly– + O (3P) at 298 K ” Poutsma, J. C.; Midey, A.; Thompson, T. H.; Viggiano*, A. A., J. Phys. Chem. A. 2006, 110, 11315. 21. “Proton
Affinity of Canavanine and Canaline,
Oxyanalogs of Arginine and Ornithine.” Andriole, E. J.; Colyer,
K. E.; Cornell, E.; Poutsma, J. C. J. Phys. Chem. A 2006, 110, 11501. 20. “Theoretical and Experimental
Investigation of the Energetics of Cis-Trans
Proline Isomerization in Peptide Models” Carper, E. M.; Schroeder, O. E.;
Wind, J. J.; Poutsma J. L. Etzkorn, F.A. ; Poutsma*, J. C., J. Phys. Chem. A 2006 110, 6522. 19. “Absolute rate coefficients for the reactions of O2– + N (4S3/2) and O2– + O (3P) at 298 K in a selected-ion flow tube instrument” Poutsma, J. C., Midey, A., Viggiano*, A. A., J. Chem. Phys., 2006. 124, 074301. 18. "Proton Affinity of b-Oxalylaminoalanine (BOAA): Incorporation of Direct Entropy Correction into the Single Reference Kinetic Method" Wind, J. J.; Papp, L. D.; Happel, M.; Hahn, K.; Andriole, E. J. ; Poutsma, J. C., J. Am. Chem. Soc. Mass Spectrom. 2005, 16, 1151. 17. "Experimental Chloride Ion Affinities and Theoretical Predictions for the Absolute Heats of Formation of SiCl2 and SiClF." Poutsma, J. C.; Schroeder, O. E.; Squires, R. R. Chem. Phys. Lett. 2004, 389, 433. 16. "The Proton Affinity of Lysine Homologues from the Extended Kinetic Method" Schroeder, O. E.; Andriole, E. J.; Carver, K. L.; Colyer, K. E.; Poutsma, J. C. J. Phys. Chem. A. 2004, 108, 326. 15. “cis-1,5-diaminocyclooctane: The Most Basic Gaseous Primary Amine?” Poutsma*, J. C.; Andriole, E. J.; Sissung, T.; Morton*, T. H. Chem. Comm. 2003, 16, 2040. 14. “The Absolute Heat of Formation and Singlet-Triplet splitting for HCCN” Poutsma,* J. C.; Upshaw, S. D.; Squires, R. R.; Wenthold, P. G.,J. Phys. Chem. A 2002, 106, 1067. 13. “Proton Affinity of Proline Analogs using the Kinetic Method with Full Entropy Analysis” Kuntz, A. F.; Boynton, A. W.; David, G. A.; Colyer, K. E.; Poutsma, J. C. J. Am. Soc. Mass Spectrom. 2002, 13, 72.
Siena Pictures |
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