Description: Description: Description: JC and Governer Kaine


Welcome to the Poutsma Group
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J. C. Poutsma

Garrett-Robb-Guy Professor of Chemistry

Garrett-Robb-Guy Chair 2017-2022

English-Stonehouse Faculty Fellow 2013-2015

2011 Plumeri Award for Faculty Excellence

2008 Professeur Invitee, Universite Pierre et Marie Curie
2006 Henry Dreyfus Teacher Scholar
2004 NSF CAREER Award

B.S., Furman University 1991 
Ph.D., Purdue University 1997
Research Associate, Stanford University 1997-99

(757)-221-2548; e-mail:

Courses        Research Interests    Current Students  
  Current Funding     Mass Spectrometry Links



Chem. 103 General Chemistry (Fall 2018)

Chem. 302, Second Semester Physical Chemistry

Chem. 303 Integrated physical/analytical lab I (Fall 2018)

Chem. 304 Integrated physical/analytical lab II

Chem. 309, Principles of Instrumental Analysis

Chem. 404, Advanced Analytical Chemistry

Chem. 408 Computational Methods in Chemistry

Chem. 460 Mass Spectrometry (Spring 2018)

Research Interests


We use mass spectrometry and high-level theoretical calculations to study the intrinsic properties of gas-phase biomolecules.  We are especially interested in the chemistry of so called “non-protein amino acids”, which are naturally-occurring compounds that are not coded by RNA. These species serve as model systems for us to understand the subtle interplay between structure and function in biological molecules.


Current projects in the lab include:


1)  Gas-phase thermochemistry of protein and non-protein amino acid using the extended kinetic method.

2)  Peptide fragmentation mechanisms

3)  Hydrogen-deuterium exchange of biomolecules

4)  Infrared multiphoton dissociation spectroscopy

5)  Studies of entropy effects in the kinetic method

6)  Proteomics studies of bacteriophages and mycobacteria


We have a variety of instrumentation in our lab, including:

Image result for Thermo LTQ xl with ETD

Image result for Thermo TSQ quantum ultra

Shimadzu UPLC – Thermo LTQ-XL with ETD

TSQ quantum classic triple quadrupole

2 LCQ DECA ion traps











Current Students

Research Group (Poutsma's Army)
Fall 2018

Amy Schienschang

 Christian Harris

Dani Long

Izzy Owens

B.S. 2009 Randolph College, MS candidate

Class of 2019

Class of 2019

Class of 2019

Image may contain: Valentina Masiero, smiling


Anwar Radwan

Valentina Masiero

Gwen Turner

William Moeller

Class of 2019

Class of 2020

Class of 2020

Class of 2021


Former Students (Rogue's Gallery)


Group Photos

Summer 2014

Twins Game 2013

ASMS 2013

ASMS 2013 (w/ Fred McLafferty)

ASMS 2013



W&M UG symposium 2011

ASMS 2010

ASMS 2002

Students in timeout box

Charlotte under timeout table

more students in timeout box

safety first when in the box

safety first when working at the hood

Rita and Corbin working hard

LN2 ice cream (bacon flavor)

The Red Iguana in Salt Lake City

moose guarding the gate valves

group at King’s Dominion

Current Funding

National Science Foundation CSDM-B  CHE-1800137 (2018-2021)

National Institutes of Health R15 (2015-2019)



William and Mary Students are Underlined

39        “Infrared Multiple Photon Dissociation Spectroscopy of Cationized Canavanine: Side-Chain Substitution Influences Gas-Phase Zwitterion Formation.Smith, Z. M.; Steinmetz, V.; Martens, J.; Oomens, J.; Poutsma*, J. C. Int. J. Mass Spectrom., 2018, 429, 158.

38.       Metal Substitution and Solvomorphism in Alkylthiolate-Bridged Zn3 and HgZn2 Metal Clusters.” Hallinger, M. R.; Gerhard, A. C.; Ritz, M. D.; Sacks, J. S.; Poutsma, J. C.; Pike, R. D.; Wojtas, L.; Bebout*, D. C. ACS Omega 2017, 2, 6391.

37.       C–HO Hydrogen Bonding in Pentamers of Isatin.Silski, A. M.; Brown, R. D.; Petersen, J. P.; Coman, J. M.; Turner, D. A.; Smith, Z. M.; Corcelli, S. A.; Poutsma, J. C.; Kandel*, S. A. J. Phys. Chem. C. 2017,  121, 21520.

36.       “Infrared Multiple-photon Dissociation Action Spectroscopy of the b2+ ion from PPG: Evidence of third residue affecting b2+ fragment structure.” Poutsma*, J.C.; Martens, J.; Oomens J.; Maitre, P.; Steinmetz, V.; Bernier, M.; Jia, M.; Wysocki*, V. H. J. Am. Soc. Mass Spectrom., 2017, 28, 1482-1488.

35.       “Infrared Spectroscopic Confirmation of α-Lactone Formation in the Dissociation of a Gaseous Amino Acid”, Wenthold*, P. G.;  Koirala,D.; Somogyi, A.; Poutsma, J. C. J. Phys. Org. Chem., 2017, 30, e3606.

34.        Investigation of Proton Affinities, Dimer Equilibria, and Gas Phase Vibrational Spectra of Protonated Nucleosides, Deoxynucleosides, and Their Analogues” Ung, H. U.; Arias, E.; Huynh, K. T.; Poutsma, J. C.; Oomens, J.; Berden, G.; Morton, T. H. Int. J. Mass Spectrom., 2015, 378, 294.

33.        Gas-Phase Acid-Base Properties of 1-Aminocycloalkane-1-Carboxylic Acids from the   Extended Kinetic Method.Muetterties, C; Drissi Touzani, A.; Hardee, I.; Huynh, K. T.; and Poutsma, J. C. Int. J. Mass Spectrom., 2015, 378, 59.

32.        “Investigations of the Mechanism of the "Proline Effect" in Mass Spectrometry Peptide Fragmentation Experiments: the “Pipecolic Acid Effect.” Raulfs, M. M.; Breci, L.; Bernier, M., Hamdy, O.; Janiga, A.;Wysocki., V.; Poutsma, J. C.  J. Am. Soc. Mass Spectrom., 2014, 25, 1705.

31.        Gas-Phase Acid-Base Properties of Homocysteine, Homoserine, 5-Mercaptonorvaline, and 5-Hydroxynorvaline from the Extended Kinetic Method.” Muetterties, C.; Janiga, A.;  Huynh, K. T.; Pisano, M. G.; Tripp, V. T.; Young, D. D.; and Poutsma, J. C. Int. J. Mass Spectrom., 2014, 369, 71.

30.        “Macrocyclic (CdS)6 Bis-carbonato Complex Self-Assembly” Lai, W.; Berry, S.; Tran, A.; Kaplin, W.; Hain, M.; Poutsma, J.; Butcher, R.; Pike, R.; Bebout*, D. Inorg. Chem., 2013, 52, 2286.

29.        “Gas-Phase Hydrogen Deuterium Exchange of Lysine Homologs” Arrington, J. V; Straus, R.;  Reynolds, P. F.; Poutsma, J. L.; Marzluff, E. M.; Poutsma, J. C., Int. J. Mass          Spectrom., 2012, 330-332, 200.

28.        "Gas-Phase Acidities of Lysine Homologues and Proline Analogs from the Extended Kinetic Method" Webb, I.; Muetterties, C.; Platner, C. B.; Poutsma, J. C Int. J.         Mass Spectrom. 2012 316-318, 126.

27.        “A Synthetic Model of Hg(II) Sequestration” Viehweg, J. A.; Stamps, S. M.; Dertinger, J. J.; Green, R. L.; Harris, K. E.; Butcher, R. J.; Andriole, E. J.; Poutsma, J. C.; Berry, S. M.; Bebout*, D. C. J. Chem. Soc. Dalton Trans 201039, 3174.

26.        “The Curtin-Hammett Principle in Mass Spectrometry  Haupert, L.; Poutsma*, J. C.; Wenthold*, P. G. Acc. Chem. Res., 2009, 42, 1480.

25.        “IRMPD Spectroscopy Shows That AGG Forms an Oxazolone b2+ Ion” Yoon, S.H; Chamot-Rooke, J; Perkins, B. R.; Hilderbrand, A.; Poutsma, J. C.; Wysocki*, V. H.  J. Am. Chem. Soc. 2008, 130, 17644.

24.        “Gas Phase Acidities of the 20 Protein Amino Acids” Jones, C. M.; Bernier, M.; Colyer, K. E;  Carson, E.; Metz, R. Pawlow, A; Webb, I. K.; Wischow, E. D.; Andriole, E. J.; Poutsma, J. C.  Int. J. Mass Spectrom, 2007, 267, 54.

23.        “Are Carboxyl Groups the Most Acidic Sites in Amino Acids?  Gas Phase Acidity, H/D Exchange Experiments, and Computations on Cysteine and It’s Conjugate Base” Tian, Z.; Pawlow, A.; Poutsma*, J. C.;   Kass*, Steven R. J. Am. Chem. Soc. 2007, 129, 5403.

22.        “Absolute Rate Coefficients and Branching Percentages for the reactions of POxCly + N (4S3/2) and POxCly +  O (3P) at 298 K ” Poutsma, J. C.; Midey, A.; Thompson, T. H.; Viggiano*, A. A., J. Phys. Chem. A. 2006, 110, 11315.

21.        “Proton Affinity of Canavanine and Canaline, Oxyanalogs of Arginine and Ornithine.” Andriole, E. J.; Colyer, K. E.; Cornell, E.; Poutsma, J. C. J. Phys. Chem. A 2006, 110, 11501.

20.        “Theoretical and Experimental Investigation of the Energetics of Cis-Trans Proline Isomerization in Peptide Models” Carper, E. M.; Schroeder, O. E.; Wind, J. J.; Poutsma J. L. Etzkorn, F.A. ; Poutsma*, J. C.,  J.  Phys. Chem. A 2006 110, 6522.

19.        “Absolute rate coefficients for the reactions of O2 + N (4S3/2) and O2 + O (3P) at 298 K in a selected-ion flow tube instrument”  Poutsma, J. C., Midey, A., Viggiano*, A. A., J. Chem. Phys., 2006. 124, 074301.

18.        "Proton Affinity of b-Oxalylaminoalanine (BOAA): Incorporation of Direct Entropy Correction into the Single Reference Kinetic Method" Wind, J. J.; Papp, L. D.; Happel, M.; Hahn, K.; Andriole, E. J. ; Poutsma, J. C., J. Am. Chem. Soc. Mass Spectrom. 2005, 16, 1151.

17.        "Experimental Chloride Ion Affinities and Theoretical Predictions for the Absolute Heats of Formation of SiCl2 and SiClF." Poutsma, J. C.; Schroeder, O. E.; Squires, R. R. Chem. Phys. Lett. 2004, 389, 433.

16.        "The Proton Affinity of Lysine Homologues from the Extended Kinetic Method" Schroeder, O. E.; Andriole, E. J.; Carver, K. L.; Colyer, K. E.; Poutsma, J. C. J. Phys. Chem. A. 2004, 108, 326.

15.        cis-1,5-diaminocyclooctane: The Most Basic Gaseous Primary Amine?”  Poutsma*, J. C.; Andriole, E. J.; Sissung, T.; Morton*, T. H.  Chem. Comm. 2003, 16, 2040.

14.        “The Absolute Heat of Formation and Singlet-Triplet splitting for HCCN” Poutsma,* J. C.; Upshaw, S. D.; Squires, R. R.; Wenthold, P. G.,J. Phys. Chem. A 2002, 106, 1067.

13.        “Proton Affinity of Proline Analogs using the Kinetic Method with Full Entropy Analysis” Kuntz, A. F.; Boynton, A. W.; David, G. A.; Colyer, K. E.; Poutsma, J. C.  J. Am. Soc. Mass Spectrom. 2002, 13, 72.




Mass Spectrometry Links

NIST Webbook

Personal stuff

Some silly music

Versailles pictures

Siena Pictures
pictures from Governor Kaine's visit to my lab