Description: Description: Description: JC and Governer Kaine


Welcome to the Poutsma Group
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J. C. Poutsma

English-Stonehouse Professor of Chemistry

2011 Plumeri Award for Faculty Excellence

2008 Professeur Invitee, Universite Pierre et Marie Curie
2006 Henry Dreyfus Teacher Scholar
2004 NSF CAREER Award

B.S., Furman University 1991 
Ph.D., Purdue University 1997
Research Associate, Stanford University 1997-99

(757)-221-2548; e-mail:

Courses        Research Interests    Current Students  
  Current Funding     Mass Spectrometry Links



Chem. 103 General Chemistry

Chem. 302, Second Semester Physical Chemistry

Chem. 309, Principles of Instrumental Analysis

Chem. 309 L Instrumental Analysis Lab

Chem. 354 Second Semester General Chemistry Lab

Chem. 392 Physical Chemistry Laboratory II

Chem. 404, Advanced Analytical Chemistry

Chem. 408 Computational Methods in Chemistry

Research Interests


We use mass spectrometry and high-level theoretical calculations to study the intrinsic properties of gas-phase biomolecules.  We are especially interested in the chemistry of so called “non-protein amino acids”, which are naturally-occurring compounds that are not coded by RNA. These species serve as model systems for us to understand the subtle interplay between structure and function in biological molecules.


Current projects in the lab include:


1)  Gas-phase thermochemistry of protein and non-protein amino acid using the extended kinetic method.

2)  Peptide fragmentation mechanisms

3)  Hydrogen-deuterium exchange of biomolecules

4)  Studies of entropy effects in the kinetic method

5)  Proteomics studies of bacteriophages


We have a variety of instrumentation in our lab, including:


LCQ ion trap


TSQ quantum classic triple quadrupole


Home-built flowing afterglow triple quadrupole


Current Students

Research Group (Poutsma's Army)
Fall 2014

Gracie Pisano (App. Sci. Ph.D. prog.)

Kathy Huynh (M.S. Program)

Ali Drissi

Isabel Hardee

B.S. Kennesaw State, 2013

B.S. W&M 2014

Class of 2015

Class of 2015

Meghan Montoya

Emily Parrish

Katie Henke

Denise Lee

Class of 2015

Class of 2015

Class of 2016

Class of 2016

Melanie Berger



Class of 2017




Former Students (Rogue's Gallery)


Group Photos

Summer 2014

Twins Game 2013

ASMS 2013

ASMS 2013 (w/ Fred McLafferty)

ASMS 2013



W&M UG symposium 2011

ASMS 2010

ASMS 2002

Students in timeout box

Charlotte under timeout table

more students in timeout box

safety first when in the box

safety first when working at the hood

Rita and Corbin working hard

LN2 ice cream (bacon flavor)

The Red Iguana in Salt Lake City

moose guarding the gate valves

group at King’s Dominion

Current Funding

National Science Foundation (2009-2013)



William and Mary Students are Underlined

13. The Proton Affinity of Proline Analogs Using the Kinetic Method with Full Entropy Analysis. - Kuntz, A. F.; Boynton, A. W.; David G. A. ; Colyer, K. E.; Poutsma, J. C.

J. Am. Soc. Mass Spectrom. 2002 , 13 , 72.
14. The Heat of Formation and Singlet-Triplet Splitting of Cyanocarbene. - Poutsma, J. C., Upshaw, S. D. , Squires, R. R., Wenthold, P. G.,

J. Phys. Chem. A , 2002 , 106 , 1067.
15. cis-1,5-diaminocyclooctanediamine: The Most Basic Primary Amine? - Poutsma, J. C., Andriole, E. J ., Sissung, T., Morton, T. H.

Chem. Comm. , 2003 , 16 , 2040.
16. The Proton Affinity of Lysine Analogs from the Extended Kinetic Method. - Schroeder, O. E.; Andriole, E. J.; Hessler, K.; Poutsma, J. C,.

J. Phys. Chem. A., 2004 , 108 , 326.
17. Experimental Chloride Ion Affinities and Theoretical Predictions for the Absolute Heats of Formation of SiCl2 and SiClF. - Poutsma, J. C.; Schroeder, O. E. ; Squires, R. R.

Chem. Phys. Lett., 2004 , 389 , 433.
18. Proton Affinity of ß-Oxalylaminoalanine (BOAA): Incorporation of direct entropy correction into the single reference kinetic method. - Wind, J. J.; Papp, L. D.; Andriole, E. J. ; Poutsma, J. C.,

J. Am. Soc. Mass Spectrom. , 2005, 16, 1151.
19. Absolute rate constant for the reaction of O 2 with O (3P) and N (4 S3/2 )  at 298 K. - Poutsma, J.C., Midey, A., Viggiano, A. A.,

J. Chem. Phys. , 2006 , 124, 074301.
20. Theoretical and Experimental Investigation of the Energetics of cis-trans Proline Isomerization in Peptide Models. - Schroeder, O. E; Carper, E. R; Wind, J. J.; Etzkorn, F. A.; Poutsma, J. L; Poutsma, J. C.,

J. Phys. Chem. A. , 2006 , 110 , 6522
21. Proton Affinity of Canavanine and Canaline, Non-Protein Amino Acid Analogs of Arginine and Ornithine from the Entropy-Corrected Extended Kinetic Method. - Andriole, E. J.; Colyer, K. E.; Cornell, E. ; Poutsma, J. C.

J. Phys. Chem. A, 2006,  110 , 11501.
22.  Absolute Rate Coefficients and Branching Percentages for the reactions of POxCly + N (4S3/2) and POx Cl y +  O (3P) at 298 K. - Poutsma, J. C.; Midey, A., Thompson; T. H.; Viggiano, A. A., J. Phys. Chem. A, 2006 , 110, 11315.
23. “Are Carboxyl Groups the Most Acidic Sites in Amino Acids? Gas-Phase Acidity, H/D Exchange Experiments, and Computations on Cysteine and Its Conjugate Base. - Tian, Z. Poutsma, J. C.; Pawlow, A. Kass, S. R.

J. Am. Chem. Soc., 2007 ,  129 , 5403.
24. Gas Phase Acidities of the 20 Protein Amino Acids. - Jones, C. M.; Bernier, M.; Colyer, K. E.; Carson, E.; Metz, R.; Pawlow, A; Webb, I. K.;Wischow, E. D.; Andriole, E. J.; Poutsma, J. C.

Int. J. Mass Spectrom.. 2007, 267, 54.
25. IRMPD Spectroscopy Shows that AGG Forms an Oxazolone b2 + Ion. - Yoon, S.H.; Chamot-Root, J.; Perkins, B. R.; Hilderbrand, A. Poutsma, J. C. Wysocki, V. H.

J. Am. Chem. Soc. 2008, 130 , 17644.
26. The Curtin-Hammet Principle in Mass Spectrometry. - Haupert, L; Poutsma, J. C; Wenthold, P. G.

Acc. Chem. Res. 2009, 42, 1480.
27. A Synthetic Model of Hg(II) Sequestration. - Viehweg, J. A.; Stamps, S. M.; Dertinger, J. J.; Green, R. L.; Harris, K. E.; Butcher, R. J.; Andriole, E. J.; Poutsma, J. C.; Berry, S. M.; Bebout*, D. C.

J. Chem. Soc. Dalton Trans 2010, 39, 3174.

28. Gas-Phase Acidities of Lysine Homologues and Proline Analogs from the Extended Kinetic Method - Webb, I.; Muetterties, C.; Platner, C. B.; Poutsma, J. C

Int. J.Mass Spectrom. 2012 316-318, 126.

29. Gas-Phase Hydrogen Deuterium  Exchange of Lysine Homologs. - Arrington, J. V; Straus, R.;  Reynolds, P. F.; Poutsma, J. L.; Marluff, E. M.; Poutsma, J. C.

Int. J. Mass Spectrom., 2012, 330-332, 200.

30.“Macrocyclic (CdS)6 Bis-carbonato Complex Self-Assembly” Lai, W.; Berry, S.; Tran, A.; Kaplin, W.; Hain, M.; Poutsma, J.; Butcher, R.; Pike, R.; Bebout*, D. Inorg. Chem., 2013, 52, 2286

31. “Gas-Phase Acid-Base Properties of Homocysteine, Homoserine, 5-Mercaptonorvaline, and 5-Hydroxynorvaline from the Extended Kinetic Method.” Muetterties, C.; Janiga, A.;  Huynh, K. T.; Pisano, M. G.; Tripp, V. T.; Young, D. D.; and Poutsma*, J. C. Int. J. Mass Spectrom., 2014, 369, 71.

32“Investigations of the Mechanism of the "Proline Effect" in Mass Spectrometry Peptide Fragmentation Experiments: the “Pipecolic Acid Effect.” Raulfs, M. M.; Breci, L.; Bernier, M., Hamdy, O.; Janiga, A. and Wysocki., V.; Poutsma*, J. C.  J. Am. Soc. Mass Spectrom., in press.



Mass Spectrometry Links

NIST Webbook

Personal stuff

Some silly music

Versailles pictures

Siena Pictures
pictures from Governor Kaine's visit to my lab