Lisa M. Landino

Associate Professor of Chemistry

B.S. Nazareth College, Rochester, New York. (Chemistry/French) Ph.D. Department of Chemistry, University of Virginia, May 1994 Graduate Advisor: Tim Macdonald Postdoctoral Fellow, Department of Biochemistry Vanderbilt University School of Medicine, July 1994- June 1997 Postdoctoral Advisor: Larry Marnett

Contact Info

Department of Chemistry The College of William and Mary P.O. Box 8795 Williamsburg, VA 23187

Office: Integrated Science Center 1052 Email: lmland@wm.edu Phone: (757) 221-2554

Teaching

Fall 2008

Chemistry 415 – Advanced Biochemistry

Chemistry 353 – Organic Chemistry II Lab

Spring 2009

Chemistry 414 – Biochemistry (all those metabolic pathways!)

Chemistry 420 – Biochemistry Lab

Research

My research focuses on oxidative damage to proteins and its role in neurodegeneration and aging. Oxidative damage plays a role in many diseases including Alzheimer’s and Parkinson’s. Currently, we are studying the interactions of native and oxidized tubulin with other proteins and with small molecule redox regulators including nitric oxide and glutathione.

All projects in the lab use the techniques of protein biochemistry including: column chromatography for protein purification, SDS-PAGE, Western blotting, labeling of proteins with fluorescent molecules, reverse phase HPLC, and UV/Visible spectroscopy.

Microtubule structure

3.5 Ǻ structure of the tubulin dimer

Stay tuned for more details!